What is a potential risk associated with long-term corticosteroid use?

Long-term use of corticosteroids is strongly associated with the risk of developing osteoporosis. Corticosteroids can interfere with the body's ability to absorb calcium and can also inhibit the formation of new bone. Over time, this can lead to decreased bone density, making bones more fragile and susceptible to fractures. The impact on bone metabolism is a critical concern with prolonged corticosteroid therapy, particularly in individuals who may already have risk factors for osteoporosis. This relationship emphasizes the importance of monitoring bone health and considering preventive measures, such as calcium and vitamin D supplementation, when patients are prescribed long-term corticosteroids.