Which of the following actions demonstrates safe practice when handling medications?

Checking for allergies before administering medications is a fundamental safety measure in pharmacological practice. It is crucial because allergic reactions can range from mild to life-threatening, and knowing a patient's allergy history allows healthcare providers to prevent potential adverse reactions. This action exemplifies a proactive approach to patient safety and aligns with the protocols for safe medication administration.

The other actions listed do not prioritize patient safety. Administering medications based solely on the time disregards important aspects like the patient's condition or potential contraindications. Relying on verbal directions without written confirmation can lead to misunderstandings and errors. Filling multiple prescriptions at once can increase the likelihood of mistakes, such as giving a patient the wrong medication or the wrong dosage, as it may compromise the thorough checking of each prescription's details. Thus, checking for allergies is the only action that unequivocally demonstrates a commitment to safe medication handling.